Analysis of Factors that Influence Hematopoietic Recovery in Autologous Transplanted Patients with Hematopoietic Stem Cells from Peripheral Blood

Grubovik Rastvorceva, Rada and Georgievski, Borce and Cevreska, Lidija and Genadieva-Stavric, Sonja and Grubovic, Milos R. (2017) Analysis of Factors that Influence Hematopoietic Recovery in Autologous Transplanted Patients with Hematopoietic Stem Cells from Peripheral Blood. Open Access Macedonian Journal of Medical Sciences, 5 (3). pp. 324-331. ISSN 1857-9655

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Abstract

BACKGROUND: Successful hematopoietic stem cell transplantation (HSCT) requires a rapid and durable
hematopoietic recovery.
AIM: The aim of our study was to analyse factors that influence hematopoietic recovery after autologous HSCT.
MATERIALS AND METHODS: Multiple regression analysis was used to analyse factors affecting neutrophil and
platelet engraftment in 90 autologous transplanted patients – 30 with acute myeloid leukaemia (AML), 30 with
lymphoma and 30 with multiple myeloma (MM) from 2008 till 2016.
RESULTS: The neutrophil recovery in AML patients was significantly influenced by transfusion support with
random-donor platelets, sex and number of transplanted mononuclear cells (MNC) and CD34+ cells; and in
lymphoma patients, it was influenced by sex, age, mobilisation strategy and some transplanted MNC. The
influence of investigated factors on neutrophil engraftment in MM patients was not statistically significant. The
platelet recovery in AML patients was influenced by transfusion support with random-donor platelets; in lymphoma
patients, it was influenced by sex, age, time from diagnosis to harvesting and time from diagnosis to HSCT; and in
MM patients it was influenced by transfusion support with random-donor platelets.
CONCLUSION: Additional studies are necessary to better understanding of engraftment kinetic to improve the
safety of HSCT and to minimise potential complications and expenses related to HSCT.

Item Type:	Article
Impact Factor Value:	1.117
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Rada Grubovik Rastvorceva
Date Deposited:	15 Aug 2022 09:27
Last Modified:	15 Aug 2022 09:29
URI:	https://eprints.ugd.edu.mk/id/eprint/30009

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