Correlation between post 5 ARI syndrome and dehidroepianderosterone levels in patients with BPH

Sofronievska, Maja (2020) Correlation between post 5 ARI syndrome and dehidroepianderosterone levels in patients with BPH. Knowledge International Journal (KIJ), 38 (4). pp. 663-669. ISSN 1857-923X / 2545-4439 printed

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Abstract

Abstract: Conservative or non-surgical treatment of benign prostatic hyperplasia relies on the use of mainly two groups of medicines: selective alpha blockers and 5 alpha reductase inhibitors (5ARI). The most efficient non-surgical treatment is combination therapy of these medicines but occasionally after the introduction of 5ARI in the treatment, certain adverse effects that include sexual disturbances and depression may appear that are known as "post-5 ARI syndrome". The purpose of this study is to show the significance and role of the dehydroepiandrosterone as an important predictor of post-5ARI syndrome in patients with BPH who are treated with 5ARI. In this randomized controlled prospective pharmaco epidemiological study, we investigated 120 patients with BPH combination therapy (tamsulosin and dutasteride) versus control group that consisted of 130 patients with monotherapy for BPH (tamsulosin).The correlation between both erectile dysfunction and depression on one side an serum dehydroepiandrosterone levels on the other was investigated at the time of active use of therapy in period of 6 months. We evaluated two groups of patients through 3 questionnaires: IPSS (International Prostate Score System) to evaluate the symptoms of benign prostatic hyperplasia (BPH), IIEF (International Index for Erectile Function) questionnaire for erectile dysfunction (ED) and a Beck depression inventory (BDI). We concluded that there is a law-proportionate correlation between appearance of post 5APJ syndrome and dehydroepiandroserone levels in patients with BPH.
Keywords: BPH, erectile dysfunction, depression, dehydroepiandrosterone, post 5APJ 1.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Maja Sofronievska
Date Deposited:	15 Aug 2022 09:22
Last Modified:	15 Aug 2022 09:22
URI:	https://eprints.ugd.edu.mk/id/eprint/29977

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