Impact of intensity modulated radiation therapy on the salivary glands function and saliva flow rate

Rogoleva Gjurovski, Sonja and Popovski, Vladimir and Kostadinova, Lenche and Nikolovski, Bruno (2022) Impact of intensity modulated radiation therapy on the salivary glands function and saliva flow rate. Journal of Morphological Sciences, 5 (1). pp. 172-178. ISSN 2545-4706

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Abstract

In patients with head and neck cancer, the most common issue after radiation treatment is xerostomia and the consequences of that, which are affecting the quality of everyday life of the patient. Subjectively xerostomia is manifested as dryness in the oral cavity, followed with obstructed chewing and swallowing of the food. Mostly it happens because of the death of the cells in the gland that are supposed to be dividing, caused by the radiation. To improve patients’ life after treatment, IMRT approach has been considered to be a better solution for the gland tissue sparing during the radiation treatment, therefore, to decrease the severity and the intensity of the following xerostomia. The IMRT technique allows the chosen dose of radiation to be applied specifically on the tissue where it is supposed to be, sparing the surrounding healthy parts from the unnecessary radiation.
The aim of this study was to evaluate the influence of the Intensity Modulated Radiation therapy (IMRT), with different intensity and dosage, on the function of salivary glands.
For this study were analyzed total number of 87 surveys, 41 of them were used for detail analysis. This study is based on narrative review on published articles written in English language, reporting results related to the use of Intensity modulated radiation therapy treatment in patients with head and neck cancer. The wide research was done using the data bases of PubMed (Medline), NCBI (US National Library of Medicine), Medscape, Webmd, Mdconsult, Emedicine, Google scholar, and Cochrane Library.
The gathered results have shown that the function of the salivary glands after radiation treatment can be in many cases protected during the treatment, or even restored to some level, therefore the resulting xerostomia can be reduced and its’ following negative effects affecting the patients’ life could be minimized by using the improved technique IMRT. In many studies the evaluated levels of xerostomia have been found to be significantly lower in the groups of patients treated with IMRT technique, compared with the other group of patients treated with conventional radiation therapy. Also, a big influence has the dosage of the radiation beams, on what depends on the outcome of the salivation function in patients treated with radiation therapy.

Item Type:	Article
Subjects:	Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Sonja Rogoleva Gurovski
Date Deposited:	09 May 2022 09:54
Last Modified:	09 May 2022 09:54
URI:	https://eprints.ugd.edu.mk/id/eprint/29743

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