Effectiveness Study On longitudinal Laboratory monitoring Of the INR in Patients Receiving Vitamin-K Antagonist For Atrial Fibrilation in R.Macedonia

Miftari, Visar and Serafimov, Aleksandar and Demiri, Fisnik and Ismani, Ekrem (2019) Effectiveness Study On longitudinal Laboratory monitoring Of the INR in Patients Receiving Vitamin-K Antagonist For Atrial Fibrilation in R.Macedonia. Medicus International Medical Journal, 24 (3). pp. 280-285. ISSN 1409-6366

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Abstract

Atrial fibrillation is preventable cause for ischemic stroke and various other thrombo-embolic events. One of
the main agents used in the prevention of the consequences are the vitamin-K antagonists. Although efficacy is
proven, studies have questioned their efficiency in this setting. Various factors contribute to variations of their
efficiency, which is still underinvestigated in many health systems. Few studies have shown varied estimates
and cited different reasons for its effectiveness, ranging from subtle differences in diet, concurrent medications
use, variable level of enzyme activity to age and compliance of users, which can vary unexpectedly. The aim of
the present study of effectiveness is to describe how often patients that use VKA achieve the targeted values for
INR. The population consists of the hospital reach area of Clinical Hospital Tetovo, observed for 6 months with
routine laboratory investigation for the values of INR. Our study reveals that 57.4% of all measurements of INR
where within the target values between 2-3, while 9.7% of all measurements revealed extreme values that can put
patients at risk for further thrombo-embolic events or catastrophic hemorrhagic events.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences
Divisions:	Faculty of Medical Science
Depositing User:	Aleksandar Serafimov
Date Deposited:	24 Jun 2022 08:18
Last Modified:	24 Jun 2022 08:18
URI:	https://eprints.ugd.edu.mk/id/eprint/29593

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