Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease

Spasovski, Spiro and Belazelkovska, Zlatanka and Popovska, Mirjana and Atanasovska-Stojanovska, Aneta and Radojkova-Nikolovska, Vera and Muratovska, Ilijana and Tosevska Spasovska, Natasa and Dzipunova, Biljana and Nikolovski, Bruno (2016) Clinical Therapeutic Effects of the Application of Doxycycline in the Treatment of Periodontal Disease. Open Access Macedonian Journal of Medical Sciences, 4 (1). pp. 152-157. ISSN 1857-9655

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OBJECTIVE: To compare the therapeutic effects of the application of doxycycline-full dose (100 mg) and sub-dose (20 mg) in the treatment of periodontal disease.
MATERIAL AND METHODS: A total of 60 patients with periodontal disease were examined. Patients are divided into two groups: A) treated with antimicrobial dose of 100 mg doxycycline once daily for 30 days, and B) treated with 2 x 20 mg/day. doxycycline, during 75 days. Among all patients a conservative treatment was carried out and ordinated the proper dose doxycycline in total dose during treatment from 3 gr. Index of dental plaque by Löe-Sillness, index of gingival inflammation and gingival bleeding by Cowell were followed.
RESULTS: Values of dental plaque in relation first examination, 10th, 20th day, 1 month and 2.5 months, showed that after 2.5 months, average value (x = 0.83) of dental plaque in second group is slightly less than the value (x = 0.93) of dental plaque in the first group. The average value (x = 0.17) of gingival inflammation in second group is significantly less than the value (x = 0.50) of gingival inflammation in the first group. The average value (x = 0.97) of gingival bleeding in patients from the first group was significantly higher than value(x = 0.37) of gingival bleeding in the second group.
CONCLUSION: Patients whose therapy was helped by a sub-dose doxycycline demonstrated positive therapeutic effects on gingival inflammation and bleeding.

Item Type: Article
Impact Factor Value: 0.141
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Cena Dimova
Date Deposited: 27 Dec 2021 08:29
Last Modified: 27 Dec 2021 08:29

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