Molecular and histological characteristics of early triploid and partial molar pregnancies

Kubelka-Sabit, Katerina and Jasar, Dzengis and Filipovski, Vanja and Bozhinovski, Gorgi and Plasheska-Karanfilska, Dijana (2018) Molecular and histological characteristics of early triploid and partial molar pregnancies. Abstracts of Posters & Oral Presentations . The Arab Division of the International Academy of Pathology.

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Abstract

Objective: Molar pregnancy has the highest incidence of all gestational
trophoblastic diseases. This is a heterogeneous group of diseases, composed
of precancerous lesions and gestational trophoblastic tumors. The hydatidiform
mole is characterized by varying degrees of proliferation of
syncitiotrophoblastic and cytotrophoblastic cells and stromal edema. Based on
established morphological and cytogenetic criteria, molar pregnancy is divided
into partial and complete. The risk of persistent trophoblastic disease is higher
in complete mole compared with partial mole. The aim of this study was to
assess the importance of additional molecular methods as a conjunction to the
standard histopathological analysis to accurately determine the type and origin
of triploidy and to detect partial molar pregnancy.
Methods: We selected a group of 24 consecutive cases of triploidy from a total
group of 231 cases of early spontaneous abortions. All 231 cases were analyzed
using Quantitative Fluorescent Polymerase Chain Reaction (QF-PCR). Placental
and decidual tissue samples from all cases were formalin-fixed and routinely
processed. Hematoxilin and eosin stained slides were analyzed by experienced
pathologist.
Results: The QF-PCR results of the placental tissue showed that 10% of the
cases were triploid. The extra chromosomal set was of paternal origin in 9
(37.5%) cases, and of maternal origin in 15 cases (62.5%). The genotype 69, XXY
more often had maternal origin of the extra chromosomal set (10 vs 5), as well
as the genotype 69, XXX (5 vs 2). The difference was not statistically significant.
The statistical analysis confirmed the difference in median number of predictor
factors between the two groups to be statistically significant (p = 0.04),
suggesting that diandric triploidies had significantly greater number of
diagnostic parameters suggestive of partial hydatidiform mole.
Conclusion: Due to the histomorphological overlap between partial molar
pregnancy and hydropic abortions, concomitant histopathological analysis and
molecular analysis of the placental tissue can lead to a correct diagnosis.
Policy of full disclosure: /

Item Type:	Book
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine
Divisions:	Faculty of Medical Science
Depositing User:	Vanja Filipovski
Date Deposited:	06 Dec 2021 08:24
Last Modified:	06 Dec 2021 08:24
URI:	https://eprints.ugd.edu.mk/id/eprint/28881

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