Intestinal microbiota composition and the risk of colorectal cancer-novel approach of an old issue

Jasar, Dzengis and Kubelka-Sabit, Katerina and Filipovski, Vanja and Curcic Trajkovska, Biljana (2020) Intestinal microbiota composition and the risk of colorectal cancer-novel approach of an old issue. Journal of Hygienic Engineering and Design (JHED), 30. pp. 83-88. ISSN 1857- 8489

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Abstract

Colorectal cancer is a multifactorial disease involving genetic, environmental and lifestyle risk factors. As a good
example of chemical carcinogenesis, the recent studies
increased a role of the intestinal microbiota in the development of this disease. This review is an attempt to
summarize the current knowledge about the potential
links between the intestinal microbiota, dietary style
and colorectal cancer, emphasizing that changes in the
intestinal microbiota composition, interfere with cell cycle regulation and the production of toxic metabolites
that have deleterious effect on colorectal mucosa.
Different electronic databases such as PubMed, Google Scholar, and Web of Science were searched for relevant literature which has been reviewed in this article.
We found that in this literature, several bacterial species have been shown to exhibit the pro-inflammatory
and pro-carcinogenic properties, which could consequently have an impact on colorectal carcinogenesis.
On the other side bacterial microbiota modifications
through dietary style changes, could represent novel
prognostic markers and/or targets for innovative therapeutic strategies. It means that exploitation of the gut
microbiota offers opportunities for the personalization
of chemotherapeutic regimens and the development
of novel therapies for colorectal cancer patients.
Diversity of the microbial ecosystem favors organism
homeostasis, particularly at the level of the cancer-immune dialogue. Therefore, the gut microbiota is both
a target for nutritional intervention and a factor influencing the biological activity of other food compounds
acquired orally, as well as a moderator of effective anticancer therapy.

Item Type:	Article
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences
Divisions:	Faculty of Medical Science
Depositing User:	Vanja Filipovski
Date Deposited:	02 Dec 2021 20:58
Last Modified:	02 Dec 2021 20:58
URI:	https://eprints.ugd.edu.mk/id/eprint/28878

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