Anaplastic lymphoma kinase (ALK) expression in lung adenocarci-noma - clinicopathologic and morphologic features

Jasar, Dzengis and Kubelka-Sabit, Katerina and Filipovski, Vanja (2019) Anaplastic lymphoma kinase (ALK) expression in lung adenocarci-noma - clinicopathologic and morphologic features. Virchows Archiv, 475. S397-S397. ISSN 1432-2307 (electronic version) Journal no. 428

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Abstract

Background & Objectives:The aim of this study is to explore the statusof ALK in lung adenocarcinomas and to evaluate the relationship be-tween ALK expression and clinicopathological and morphological fea-tures of the primary tumour.Methods:In total, 86 cytological and biopsy specimens were tested forALK status using automated immunostainer with Ventana anti-ALK(D5F3) antibody. The expression of ALK was correlated with patient’sage, sex and histological features of the primary tumour.Results:ALK positive expression was detected in 15 (17,4%) cases, insignificantly younger age group than ALK negative patients (p<0.05).Mucinous type of lung adenocarcinomas were predominantly ALK pos-itive (43,7%), followed by papillary type (25%), acinic type (13%) andsolid type (3%). There was strong correlation between the ALK expres-sion in surgical biopsy and cytological specimens (p<0.05).Conclusion:These results represent that immunohistochemical expres-sion of ALK gene rearrangement is valid detection technique revealingdistinctive clinicopathological and morphological features of the tumourespecially in scant biopsies and cytological specimens.

Item Type:	Article
Impact Factor Value:	4.064
Uncontrolled Keywords:	Anaplastic lymphoma kinase (ALK) expression, lung adenocarcinoma, clinoco-pathological features, morphological features
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Vanja Filipovski
Date Deposited:	06 Dec 2021 08:22
Last Modified:	06 Dec 2021 08:22
URI:	https://eprints.ugd.edu.mk/id/eprint/28670

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