Retroperitoneal and pulmonary metastases from burned-out testicular germ cell tumour as initial clinical presentation: Report of two cases

Filipovski, Vanja and Kubelka-Sabit, Katerina and Jasar, Dzengis and Janevska, Vesna (2017) Retroperitoneal and pulmonary metastases from burned-out testicular germ cell tumour as initial clinical presentation: Report of two cases. Virchows Archiv, 428. S347-S348. ISSN 1432-2307 (electronic version) Journal no. 428

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Abstract

Objective: To present two cases of metastatic deposits from burned-out testicular germ cell tumours (GCTs) as initial clinical presentation of the disease.

Method: Case 1: Retroperitoneal necrotic tumour from a 40-year old male patient, and fragments from the lumbar vertebra were submitted for analysis. Case 2: Core biopsy of a lung mass from a 26-year old male patient was received for analysis. Both cases were routinely processed and additional immunoihistochemical analyses were performed.

Results: Case 1: Necrotic retroperitoneal tumour had only a few vital germ cell tumour cells positive for PLAP and CD30. In the testis, an area measuring 17 mm showed hyalinization, sclerosis and calcification with cystic structures presenting mature teratoma positive for cytokeratins 7 and 20. In the surrounding area, a component of germ cell neoplasia in situ (GCNIS) positive for PLAP was found. Case 2: Lung core biopsy reveled 1 mm focus of of embryonal carcinoma, positive for PLAP, CK7 and CD30. Testicular tissue had areas of GCNIS positive for PLAP and c-kit and 8 mm focus of hyalinization and calcification.

Conclusion: Testicular burned-out (GCT) is a rare neoplasm that initially manifests as metastatic deposits in the retroperitoneum and lung. Awareness of this phenomenon is mandatory in diagnosis of metastatic deposits.

Item Type:	Article
Impact Factor Value:	2.848
Uncontrolled Keywords:	burnt-out testicular germ cell tumor, pulmonary and retroperitoneal metastases
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Vanja Filipovski
Date Deposited:	06 Dec 2021 08:21
Last Modified:	06 Dec 2021 08:21
URI:	https://eprints.ugd.edu.mk/id/eprint/28668

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