Redox regulation of calcium ion channels: Chemical and physiological aspects

Bogeski, Ivan and Kappl, Reinhard and Kummerow, Carsten and Gulaboski, Rubin and Hoth, Markus and Niemeyer, Barbara A. (2011) Redox regulation of calcium ion channels: Chemical and physiological aspects. Cell Calcium, 50 (5). pp. 407-423. ISSN 01434160

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Reactive oxygen species (ROS) are increasingly recognized as second messengers in many cellular processes.
While high concentrations of oxidants damage proteins, lipids and DNA, ultimately resulting in
cell death, selective and reversible oxidation of key residues in proteins is a physiological mechanism
that can transiently alter their activity and function. Defects in ROS producing enzymes cause disturbed
immune response and disease.
Changes in the intracellular free Ca2+ concentration are key triggers for diverse cellular functions. Ca2+
homeostasis thus needs to be precisely tuned by channels, pumps, transporters and cellular buffering
systems. Alterations of these key regulatory proteins by reversible or irreversible oxidation alter the
physiological outcome following cell stimulation. It is therefore necessary to understand which proteins
are regulated and if this regulation is relevant in a physiological- and/or pathophysiological context.
Because ROS are inherently difficult to identify and to measure, we first review basic oxygen redox
chemistry and methods of ROS detection with special emphasis on electron paramagnetic resonance
(EPR) spectroscopy. We then focus on the present knowledge of redox regulation of Ca2+ permeable ion
channels such as voltage-gated (CaV) Ca2+ channels, transient receptor potential (TRP) channels and Orai

Item Type: Article
Uncontrolled Keywords: Ca2+ ion channels, calcium, mitochondrial Ca2+ transport, redox signalling
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Natural sciences > Matematics
Natural sciences > Physical sciences
Divisions: Faculty of Agriculture
Depositing User: Rubin Gulaboski
Date Deposited: 02 Nov 2012 10:38
Last Modified: 02 Nov 2012 10:38

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