Dyslipidemic profile relations to insulin resistance

Janikevik Ivanovska, Danijela and Shubeska Stratrova, Slavica and Domazetovska, Saska and Koloska, Valentina (2019) Dyslipidemic profile relations to insulin resistance. In: 27th Balkan Clinical Laboratory Federation Meeting BCLF 2019, 30th National Congress of the Turkish Biochemical Society TBS 2019, 27-31 Oct 2019, Antalya, Turkey.

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Abstract

INTRODUCTION: Insulin resistance and atherogenic dyslipidemic profile are the main
characteristics of the metabolic syndrome. The aim of this study was to discover the positive
relation between atherogenic dyslipidemic profile and increased insulin resistance determined
through homeostatic model assessment (HOMA) in obese women subjects.
MATERIALS AND METHODS: HOMA (H) was determined as a ratio of the multiplied fasting
glucose (G0) and insulin levels (I0) divided with 22.5 (G0xI0/22.5). According to H the patients
were divided in 3 groups: 1
st gr. H<4 and BMI 28±8kg/m2
, 2nd gr. H=4-8 and BMI 40±73.8kg/m2
and the 3rd gr. H>8 and BMI 41±68kg/m2
. The examinees were 90 women divided in 3 equal
groups not different according to their age. Triglycerides (TG), total cholesterol (TC), high
density lipoprotein (HDL-C), low density lipoprotein LDL-C, expressed in mmol/l and indexes
of the atherogenic risk C/HDL-C and LDL/HDL-C were determined.
RESULTS: First group had TG values 1.05±0.48, TC 4.8±0.79, HDL-C 1.19±0.47, LDL-C
3.27±0.76, C/HDL-C 3.05±1.18, LDL/HDL-C 4.45±1.48. In the 2nd group the patients had
higher correspondent values: 1.39±1.01, 4.97±0.88, 1.04±0.33, 3.33±0.48, 3.62±1.42 and
5.33±1.72.
DISCUSSION: Patients in the 3rd gr. had significantly higher TG levels 1.8±0.8 (p<0.001),
significantly lower HDL-C levels 0.88±0.19 (p<0.011), significantly higher C/HDL-C ratio
4.2±1.32 (p<0.015) and LDL/HDL-C had significantly higher level 5.26±1.69 (p<0.003).
HOMA index correlated significantly with TG (p<0.001), LDL-C (p<0.011), C/HDL-C
(p<0.001), LDL/HDL-C (p<0.001) and significantly negatively with HDL-C (p<0.001).
CONCLUSION: HOMA correlated significantly to dyslipidemic profile and was confirmed as a
good indicator of insulin resistance. It was confirmed that insulin resistance determined with
HOMA index was associated with dyslipidemic profile.

Item Type: Conference or Workshop Item (Paper)
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health biotechnology
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Danijela Janikevik
Date Deposited: 11 Mar 2021 11:12
Last Modified: 11 Mar 2021 11:12
URI: https://eprints.ugd.edu.mk/id/eprint/27919

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