Anti –tpo and anti-tg antibodies in autoimmune thyroide diseases diagnosis

Janikevik Ivanovska, Danijela and Shubeska Stratrova, Slavica and Domazetovska, Saska and Gorgeska, Biljana and Evtimovska, Nina (2017) Anti –tpo and anti-tg antibodies in autoimmune thyroide diseases diagnosis. In: Clinical Chemistry and Laboratory Medicine, 13 June 2017, Athens, Greece.

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Abstract

Background: Irrespective of the recommendations of the use of serum TSH as a cornerstone of thyroid function testing,the laboratory diagnosis and monitoring of thyroid disease are based on the thyroid panel including anti-TPO and anti-TG,which are essential to manage thyroid diseases especially autoimmune thyroid diseases Graves’ disease and Hashimoto’sthyroiditis.
Methods: In this clinical study prospective assessment of the morning serum anti-TPO and anti-TG concentrations were performed in 50 subjects with Graves’ disease and 50 with Hashimoto’s thyroiditis and 40 healthy subjects. Serum concentrations of anti-TPO and anti-TG were determined by chemiluminescence immunoassay of CLIA methods analyzer Immulite 2000.
Results: Patients with Graves’ disease and Hashimoto’s thyroiditis showed significantly higher concentrations of anti-TPO and anti-TG compared with healthy individuals (P <0.001). Anti-TPO values in the control group were 3.7± 0.46 IU/ml and anti-TG values were 10±0.05 IU/ml, significantly lower (P<0.001) compared to anti-TPO values (238.5 ± 7.95 IU/ml) in Graves’ disease and (333.3 ± 8.55 IU/ml) in Hashimoto’s thyroiditis. Anti-TG values in the control group were 10±0.55 IU/ml, significantly lower (P<0.001) compared to anti-TG values (42 ± 4.95IU/ml) in Graves’ disease and (53.3 ± 0.55Ul/ml) in Hashimoto’s thyroiditis.
Conclusion: Serum concentrations of anti-TPO and anti-TG respectively as organ specific autoantibodies are very precious parameters that enable precise and fast Graves’ disease and Hashimoto’s thyroiditis diagnosis.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Danijela Janikevik
Date Deposited:	05 Mar 2021 08:38
Last Modified:	05 Mar 2021 08:38
URI:	https://eprints.ugd.edu.mk/id/eprint/27854

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