Jakjimoska, Verica and Cubrinoska, Marina and Trojacanec Piponska, Sonja (2018) Clinical significance of the combination of CEA and CA 19-9 tumor markers in malignant and benign tumors of various origins. In: The 26th Meeting of the Balkan Clinical Laboratory Federation The 6th National Congress of the Macedonian Association of Medical Biochemistry and Laboratory Medicine, 3-5 Oct 2018, Skopje.
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Abstract
Aim: The present study aimed to assess the diagnostic and prognostic value of clinical tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen-19.9 (CA-19.9), used in combination as helpful diagnostic method for malignant and benign tumors from different origin. Smoking habitof patients was considered as a factor for evaluation of the risk of malignancy development.
Method: The electro-chemiluminescenceimmunomethod was performed with automated analyzer to detect the levels of the two tumor markers in 71 patients, part of whom had malignant or benign tumor and the other part were without tumor. The statistical program StatsDirect was used for statistical analyses.
Results:Combined use of two tumor markers CEA and CA 19-9 can allow mistakes in diagnosing malignant and benign diseases because these tumor markers do not have 100% sensitivity and specificity. Combined specificity for malignant tumors was 92.45% and for benign tumors 82.26%. Combined sensitivity for malignant tumors was 44.44% and for benign tumors 11.11%. Smoking as a risk factor for malignant disease was calculated in 1.4.
Conclusion:7.55% of patients would have been diagnosed with malignant diagnosis incorrectly, while 55.56% of patients with such a disease would remain undetected.17.74% of patients would have been diagnosed with a benign illness diagnosis, while 88.89% would remain undetected.The prevalence of malignant disease was 25.35% while of benign disease 12.68%.Smokers were 1.4 times more likely to have malignant neoplasm than non-smokers, while smoking was insignificant factor for development of benign neoplasm.
| Item Type: | Conference or Workshop Item (Lecture) |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Biljana Gorgeska |
| Date Deposited: | 28 Jan 2021 10:17 |
| Last Modified: | 28 Jan 2021 10:17 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/27044 |
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