Splenectomy for hematological disorders

Jankulovski, Nikola and Antovic, Svetozar and Kuzmanovska, Biljana and Mitevski, Aleksandar (2014) Splenectomy for hematological disorders. Прилози (Contributions). ISSN 0350-1914

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Splenectomy is therapeutic for a large host of conditions. It is a consequence of expanding the list of
disorders and liberalizing the indications for splenectomy in many diseases. Red blood cells disorders:
autoimmune hemolytic anemia, hereditary spherocytosis, hemoglobinopathies and thalassemia
are prone to splenectomy after failure of medical therapy. A variety of thrombocytopenic disorders
are improved by splenectomy, and the most common indication for splenectomy is ITP (idiopathic
thrombocytopenic purpura). Splenectomy is successful in reversing hypersplenism in a spectrum of
disease called myeloproliferative disorders. Relief of symptoms from splenomegaly is also achieved,
but it does not affect the inexorable course of the disorder. The role of splenectomy in white blood
cells disorders (leukemias and lymphomas) is only palliative and facilitates chemotherapy.
Splenectomy in patients with hemathologic disorders imparts a risk of fulminant and life threatening
infection "overwhelming postsplenectomy sepsis" that can be obviated by appropriate treatment.
Although splenectomy for hemathologic disorders is only therapeutic and not curative, the relief of
symptoms and for some disorders facilitation of chemotherapy leads to better quality of life and
longer survival.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Aleksandar Mitevski
Date Deposited: 25 Jan 2021 08:34
Last Modified: 25 Jan 2021 08:34
URI: https://eprints.ugd.edu.mk/id/eprint/27018

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