Domazetovska, Saska and Slaveska Raicki, Renata and Janikevik Ivanovska, Danijela (2018) Diabetes mellitus treatment, effects and consequences. In: The 33rd World Congress of Biomedical Laboratory Science (IFBLS), 22-26 Sept 2018, Firenze, Italy.
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Abstract
BACKGROUND-AIM
Elevated lactate concentration in circulation might have different origin due to it’s connection to tissue and organs functioning onvery subtle way. Following glucose metabolite pathways, regulation of glucose level at the patients with Diabetes Mellitus type 2 with metformin, as a correspondent between liver and pancreas glucose metabolism and release, has to be well controlled.
This was one of the aims in our follow up study. Namely, we investigate group of patients (N 50) with DM type 2 treated with
metformin for a few months. We perform measurement of few parameters that take part as substrate or product in glucose
metabolism, but the main accent of this study was at lactate level so that negative effect can be noticed and corrected.
METHODS
Level of glucose, cholesterol, LDL cholesterol as hepatic enzyme activity was measured spectrophotometry on the start and after 1 month treatment. Glucose and lactate concentration was measured in period of few months. Obtained results were submitted to statistical ANOVA model.
RESULTS
According to statistical analysis this medicament cause moderate changes in glucose, urea level and enzyme activity. Hepatic
enzymes show that this drug doesn’t cause hepato-toxic effect in a short time glucose regulation. Although we found that
cholesterol and LDL level was lightly increased, it doesn’t show statistical significant differences. Additionally, we did found increase lactate blood concentration in a very first month of treatment, previously considered as mild to moderate acidosis( 4.25 mmol/L) without additional elevation in lactate concentration despite regulation of the glucose level. Even more, at fourth month we found decreased lactate concentration in circulation also confirmed with normal hepatic enzyme activity.
CONCLUSIONS
Estimated results shows that in few month measurements, glucose level can be good regulated with metformin avoiding acidosis and side effect. Maintaining of relatively normal lactate level also shows that glucose metabolism and its release is well control and indicates that additional side mechanisms are not activated in the regulation of the same process. In support of the results, we can confirm that lactate level and enzyme activity can be together or separately considered as good marker for drug effect during the therapy.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Danijela Janikevik |
| Date Deposited: | 03 Dec 2020 09:11 |
| Last Modified: | 03 Dec 2020 09:11 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/26818 |
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