Janikevik Ivanovska, Danijela and Domazetovska, Saska and Kololoska, Valentina (2018) Immunological criteria for the differential diagnosis of thyroid disease. In: The 33rd World Congress of Biomedical Laboratory Science (IFBLS), 22-26 Sept 2018, Firenze, Italy.
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Abstract
Background: Thyroid autoimmune disease is the major factor underlying hypothyroidism and hyperthyroidism and tends to occur in a genetically predisposed population. The major thyroid autoimmune diseases are: Hashimotoʼs diseases and Gravesʼ diseases.
Methods: Quantitative measurement of antithyroid peroxidase (TPO) antibodies and autoantibodies to thyroglobulin (TG) in serum, EDTA, and heparinized plasma, as an aid in the clinical diagnosis of thyroid diseases. Serum concentration of Anti – TPO Ab and anti – TG Ab were determined by are a solid-phase, enzyme – labeled, chemiluminescent sequential immunometric assays using analyzer Immulite 2000.
Results: 30% to 50% of individuals with autoimmune hypothyroidism, will have detectable anti-Tg autoantibodies, while 50% to 90% will have detectable anti – TPO autoantibodies. In Gravesʼ disease, both types of autoantibodies are observed at approximately half of these rates. 10 percent of healthy individuals have TG autoantibodies at low levels, higher concentracions are found in 30 and 85 percent of patients with Gravesʼ diseases and Hashimotoʼs thyroiditis, respectively.
Patients with Graves disease and Hashimoto thyroiditis showed significantly higher concentrations of anti-TPO and anti-TG compared with healthy individuals. (P <0.001). Following results were obtained: values of anti-TPO in patients diagnosed with sc Groves disease compared to the control group were 3.7± 0.46, and in patients with Hashimoto thyroiditis 238,5 ± 0.95. Values of anti-TG in patients diagnosed with sc Groves disease compared to the control group were 333,3 ± 0.55, Hashimoto thyroiditis 500,5 ± 0.95.
Conclusion: The consensus opinion today is that they are merely disease markers. It is felt that the presence of competent immune cells at the site of thyroid tissue destruction in autoimmune thyroiditis simply predisposes the patient to form autoantibodies to hidden thyroid antigens.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Danijela Janikevik |
| Date Deposited: | 03 Dec 2020 09:08 |
| Last Modified: | 03 Dec 2020 09:08 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/26816 |
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