Stojkovska, Snezana and Dimitrov, Gligor and Saltirovski, Stefan and Pantos, Konstantinos and Hadzi Lega, Makjuli (2020) Autologous platelet rich plasma intracortical ovarian injection restored ovarian function and foliculogenensis in poor responders after one month: a control pilot study. Medicus, 25 (1). pp. 7-10. ISSN 1409-6366
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Abstract
Objective: The aim of our study was to evaluate whether autologous Platelet-Rich Plasma (PRP) injected in the
ovarian cortex has therapeutic potency in restoring ovarian function in poor ovarian responders (PORs) after
one-month therapy. PRP is beginning to be used in the treatment of ovarian infertility with a possible explanation for its role in improving the follicular microenvironment as well as the influence of growth factors on ovarian stem cells in postnatal oogenesis. Methods: This prospective randomized study included women who contacted
the department of IVF in the period from 2017-2018. Women were selected according to the ESHRE consensus
on the definition of PORs. A total of 30 women were divided in two groups according to the patient choice:
ovarian PRP injection (15 patients) or no intervention (15). PRP was prepared by Regen ACR®-C Kit according to
the manufacturer’s guidelines. Approximately 3-5 ml of the PRP was injected in ovarian cortex using transvaginal
ultrasound guidance. The serum concentration of FSH, LH, estradiol and AMH were determined before the
treatment and day-3 of first menstrual cycle after treatment in order to monitor ovarian function. Results: After PRP treatment, the women had significant improvement in ovarian reserve. AMH level in serum was significantly
increased, p<0,05 (p=0,02), FSH level significantly decreased, p<0,01(p=0,003) and number of antral follicles after applying the PRP significantly increased, p<0,001 (p=0,0007). Conclusions. One-month therapy with PRP has the
potency of significantly recovering ovarian function both in its hormonal and follicular development abilities.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Igor Stojanovik |
| Date Deposited: | 23 Nov 2020 09:38 |
| Last Modified: | 23 Nov 2020 09:38 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/26795 |
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