Novel method of treating ovarian infertility: is Platelet-Rich Plasma a new promising therapy in the future?

Stojkovska, Snezana and Dimitrov, Gligor and Petanovski, Zoran and Shushleski, Damjan and Saltirovski, Stefan and Matevski, Vladimir and Hadzi Lega, Makjuli and Sotirovska, Valentina and Stojanovska, Daniela and Stamenkovska, Nikoleta and Petanovska Kostova, Emilija and Latifi Isaki, Rina (2019) Novel method of treating ovarian infertility: is Platelet-Rich Plasma a new promising therapy in the future? Macedonian Medical Review, 73 (2). pp. 101-105. ISSN 0025-1097

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Introduction. In today's modern society, the treatment of patients with poor ovarian reserve presents a medical challenge of increased clinical importance. The use of platelet-rich plasma (PRP) is a new hope that improves pregnancy chances. Increased use of the PRP in a number of in vitro centers around the world as well as publication of the first experience in in vitro fertilization entailed the need for this systematic review.
Methods. PubMed, Cochrane and Ovid Medline were searched between 2000 and 2019 under the following strategy: [<PRP or plasma-rich with platelets> and <ovaries with reduced reserves or function> and <ovarian rejuvenation>]. Fourteen original articles published in medical scientific journals were analyzed in this study. The evidence level and quality assessment were made based on the most up-to-date, reliable, scientific evidence as well as from the number of additional relevant citations.
Results. Taking the current available proof and evidence into consideration, we can conclude that the PRP method improves the ovarian function and increases the chances of clinical pregnancy. In addition, we assume that, over time, the PRP method objectively improves the ovarian reserves. Recent studies support the theory of increasing the number of preantral follicles, followed by appropriate growth and reduction of follicular atresia.
Conclusion. The improvement of the quantity and quality of oocytes with the intra-ovarian application of PRP potentially suggests a new concept of ovarian aging, where the ovarian microenvironment plays a crucial role.

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Igor Stojanovik
Date Deposited: 23 Nov 2020 09:38
Last Modified: 23 Nov 2020 09:38

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