Crystal Structure and Packing Analysis of Nitrofurantoin N,N-dimethylformamide Solvate

Cvetkovski, Aleksandar and Ferretti, Valeria (2016) Crystal Structure and Packing Analysis of Nitrofurantoin N,N-dimethylformamide Solvate. Crystallography Reports, 61 (4). pp. 611-615. ISSN 1063-7745 (Print)/1562-689X (Online)

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Abstract – The N, N’-dimethylformamide solvated crystal of the drug nitrofurantoin has been prepared and analysed by single-crystal X-ray diffraction. The two co-crystallized molecules, in the 1:1 stoichiometric ratio, are linked by a medium/strong N−H···O hydrogen bond (N···O is 2.759 (3) Å) and a weaker C−H···O interaction to form isolated supramolecular adducts, that in turn are packed into the lattice framework mainly through C−H···O hydrogen bonds. Two-dimensional fingerprint plots of Hirshfeld surfaces are used to visualize, analyze and compare intermolecular interactions found in the title compound and in similar structures.

Item Type: Article
Impact Factor Value: 0.7
Subjects: Medical and Health Sciences > Basic medicine
Engineering and Technology > Chemical engineering
Natural sciences > Chemical sciences
Engineering and Technology > Materials engineering
Engineering and Technology > Nano-technology
Divisions: Faculty of Medical Science
Depositing User: Aleksandar Cvetkovski
Date Deposited: 13 Nov 2020 09:49
Last Modified: 13 Nov 2020 09:49

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