Cvetkovski, Aleksandar and Duvlis, Sotirija (2020) Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia. The International Journal of Immunogenetics , 47 (6). pp. 522-528. ISSN 1744-313X
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Abstract
Cervical cancer (CCa) is one of the most common malign diseases in women associ-ated with human papillomavirus (HPV). The virus is an initiating factor, but not suf-ficient for the development of cervical intraepithelial lesions (CIN) and CCa. The disease might be a result of the influence of host's genetic factors and polymor-phisms in inflammatory-related genes that modify the immune response to HPV and attribute to cancer susceptibility. We carried out a study to determine the associa-tion between TNF-a-238G/A and TNF-a-308 G/T polymorphisms with HPV-positive CIN and CCa in women living in the Republic of North Macedonia. Using multiplex SNaPshot analysis for single nucleotide polymorphisms (SNPs), we analysed the gen-otype and allele distributions of TNF-a-238G/A and TNF-a-308 G/T in 134 cases (HPV-positive and histologically confirmed CIN and CCa) and in 113 controls (cyto-logical and HPV-negative women). For further analysis, the case group was stratified in three subgroups (all cases: CINs+ CCa− group; CIN2+ -group and CIN1− group). Data analysed using the odds ratio (OR) and chi-square test showed the frequency of AA genotypes and A alleles are not significantly higher in cases compared to the controls for both SNPs: AA of TNF-a-238 (0.7% versus 0%) and TNF-a-308 (1.5% versus 0.9%) as well as A allelic frequency (3.0% versus 1.7%) and (13.1% versus 10.6), respectively. The comparison of the case's subgroups with the control group did not show a statistically significant difference. Compared to controls, TNF-a-238G/A and TNF-a-308 G/T are not associated with the risk of HPV associated CIN or CCa in the studied women.
| Item Type: | Article |
|---|---|
| Impact Factor Value: | 1.13 |
| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Biological sciences Engineering and Technology > Nano-technology |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Aleksandar Cvetkovski |
| Date Deposited: | 10 Nov 2020 09:35 |
| Last Modified: | 10 Nov 2020 09:35 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/26712 |
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- Association of TNF-a (rs361525 and rs1800629) with susceptibility to cervical intraepithelial lesion and cervical carcinoma in women from Republic of North Macedonia. (deposited 10 Nov 2020 09:35) [Currently Displayed]
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