Mitreva, Makedonka and Grupa avtori (2012) A framework for human microbiome research. Nature, 486 (7402). pp. 215-221.
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Abstract
A variety of microbial communities and their genes (the microbiome) exist throughout the human body, with
fundamental roles in human health and disease. The National Institutes of Health (NIH)-funded Human Microbiome
Project Consortium has established a population-scale framework to develop metagenomic protocols, resulting in a
broad range of quality-controlled resources and data including standardized methods for creating, processing and
interpreting distinct types of high-throughput metagenomic data available to the scientific community. Here we
present resources from a population of 242 healthy adults sampled at 15 or 18 body sites up to three times, which
have generated 5,177 microbial taxonomic profiles from 16S ribosomal RNA genes and over 3.5 terabases of
metagenomic sequence so far. In parallel, approximately 800 reference strains isolated from the human body have
been sequenced. Collectively, these data represent the largest resource describing the abundance and variety of the human microbiome, while providing a framework for current and future studies.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Mirjana Kocaleva Vitanova |
| Date Deposited: | 30 Nov 2012 14:26 |
| Last Modified: | 30 Nov 2012 14:26 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/2617 |
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