Krstevska, Brankica and Velkoska Nakova, Valentina and Simeonova-Krstevska, Slagjana and Jovanovska Misevska, Sasha (2016) Maternal 75-g OGTT glucose levels as predictive factors for large-for gestational age newborns in women with gestational diabetes mellitus. Archives of Endocrinology and Metabolism - AE&M , 60 (1). pp. 36-41. ISSN 2359-3997; 2359-4292 online
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Abstract
Objective: Our goal was to investigate which glucose measurement from the 75-g oral glucose tolerance
test (OGTT) has more capability of predicting large for-gestational-age (LGA) newborns of mothers
with gestational diabetes mellitus (GDM). Subjects and methods: The study group consisted of
118 consecutively pregnant women with singleton pregnancy, patients of Outpatients Department
of the Endocrinology, Diabetes, and Metabolic Disorders Clinic. All were prospectively screened for
GDM between 24th and 28th week of pregnancy and followed to delivery. Outcome measures included:
patients’ ages, pre-pregnancy BMI, BMI before delivery, FPG, 1 and 2 hour OGTT glucose values, haemoglobin
A1c at third trimester, gestational week of delivery, mode of delivery and baby birth weight.
Results: From 118 pregnancies, 78 (66.1%) women were with GDM, and 40 (33.9%) without GDM.
There were statistically significant differences (30.7 versus 5.0%, p < 0.01) between LGA newborns
from GDM and control group, respectively. Gestation week of delivery and fasting glucose levels
were independent predictors for LGA (Beta = 0.58 and Beta = 0.37 respectively, p < 0.01). Areas under
the receiver operator characteristic curve (AUC) were compared for the prediction of LGA (0.782
(0.685-0.861) for fasting, 0.719 (0.607-0.815) for 1-hour and 0.51 (0.392-0.626) for 2-hour OGTT plasma
glucose levels). Conclusion: Fasting and 1-hour plasma glucose levels from OGTT may predict LGA
babies in GDM pregnancies.
| Item Type: | Article |
|---|---|
| Impact Factor Value: | 1.5 |
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Valentina Velkovska |
| Date Deposited: | 28 May 2020 07:41 |
| Last Modified: | 28 May 2020 07:41 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/24062 |
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