Krstevska, Brankica and Misevska Jovanovska, Sasha and Simeonova Krstevska, Slagjana and Velkoska Nakova, Valentina and Serafimoski, Vladimir (2016) Maternal lipids may predict fetal growth in type 2 diabetes mellitus and gestational diabetes mellitus pregnancies. Contributions. Sec. of Med. Sci., 37 (2-3). ISSN 1857-9345
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[18578985 - PRILOZI] Maternal Lipids May Predict Fetal Growth in Type 2 Diabetes Mellitus and Gestational Diabetes Mellitus Pregnancies.pdf Download (268kB) | Preview |
Abstract
Aim: During diabetic pregnancy, complex metabolic changes occur in the lipid profile. The aim of
the study was to determine the predictive values of maternal serum lipid levels on large-for-gestational
age newborns during the third trimester in pregnancies of women with type 2 diabetes mellitus
(DM2) and gestational diabetes mellitus (GDM).
Material and methods: Data of forty-three pregnancies of women with DM2 and two hundred
women with GDM were analyzed. The analysis encompassed the following parameters: age, body
mass index (BMI), lipid parameters, HbA1c in first, second and third trimester of pregnancy,
preeclampsia and baby birth weight.
Results: DM2 and GDM groups showed statistically significant differences in the following
variables: total lipids, triglycerides, total cholesterol, BMI, age, baby birth weight, incidence of SGA
and preterm delivery (9.4 ± 2.3 vs. 11.0 ± 2.3 mmol/L, 2.4 ± 1.4 vs. 3.4 ± 1.6 mmol/L, 5.5 ± 1.2 vs.
6.4 ± 1.4 mmol/L, 30.6 ± 5.4 vs. 26.9 ± 5.2 kg/m2, 34 ± 7.8 vs. 31.5 ± 5.6 years, 3183 ± 972 vs. 3533
± 699 g., 20% vs. 7.5%, 27.9 vs. 14%, respectively, p < 0.05). Linear multiple regression analysis
demonstrated that triglycerides, LDL-C and total cholesterol were independent predictors of LGA (p
< 0.05).
Conclusion: Triglycerides and LDL-C in the third trimester of pregnancy are independent predictors
for fetal macrosomia in DM2 and GDM pregnancies. Thus, the maternal serum triglycerides and
LDL-C levels determined in the maternal blood taken in the third trimester of pregnancy may
indentify women who will give birth to LGA newborns.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Valentina Velkovska |
| Date Deposited: | 28 May 2020 07:40 |
| Last Modified: | 28 May 2020 07:40 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/24060 |
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