Petkovska, Sofija and Gulaboski, Rubin (2020) Theoretical Model in Cyclic Voltammetry of an Electrode Reaction of Water-Soluble Redox Enzymes Associated with Reversible Regenerative Reaction-MATHCAD Simulation File for Studying kinetics and thermodynamics of Enzyme-Substrate and Drug-Drug interactions. [Dataset] (Unpublished)
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DIFFUSIONAL REGENERATIVE MECHANISM IN CV 2020-MATHCAD Simulation Protocol.pdf Download (1MB) | Preview |
Abstract
In our recent work published in Croatica Chemica Acta 92 (4) (2019) 1-8 we reported on a new theoretical model of a diffusional EC‘ mechanism associated with reversible regenerative step. Model is suitable for assessing the kinetic and themrodynamic parameters relevant to hydrophilic enzymes (as citochromes) and hydrophilic substrates. The features of simulated voltammetric patterns are function of parameters related to the electrode reaction (standard rate constant of electron transfer, number of exchanged electrons, electron transfer coefficient), and they additionally depend on the kinetic and thermodynamic of regenerative reaction. We provide the readers entire simulation protocol in MATHCAD for calculation of theoretical cyclic voltammograms. Model is also relevant to study many hydrophilic drug-drug interactions. In the work published in Analytical and Bioanalytical Electrochemistry 12 (2020) 345-364, we provide a large set of experimental results relevant to drug-drug and drug-DNA interactions evaluated from the models we present in that work.
| Item Type: | Dataset |
|---|---|
| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Chemical sciences Natural sciences > Computer and information sciences Natural sciences > Matematics Natural sciences > Physical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Rubin Gulaboski |
| Date Deposited: | 21 Apr 2020 10:24 |
| Last Modified: | 21 Apr 2020 10:24 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/23986 |
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