Proving immunoglobulin E mediated allergy with allergotestes and interpretation of results

Jakjimoska, Verica and Gjorgjeska, Biljana (2019) Proving immunoglobulin E mediated allergy with allergotestes and interpretation of results. Knowledge - International Journal, Scientific Papers, 35 (4). pp. 1215-1219. ISSN 2545-4439

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Allergy is an altered, hypersensitive state of immunity of individuals, to substances in our environment that most people have no response because they do not pose a danger. Allergens are the antigens to which antibodies form in the immune response. The allergic reaction is measured by the level of endogenous circulating specific IgE and is described descriptively in the lowest level as a level that cannot be detected or is very low, up to a level that is high, very high and extremely high. IgE is synthesized in plasma cells, submucosa of the airways and gastrointestinal tracts, in the lymphoid tissue of the nose and throat, and also contains the secretions of the bronchi and the nose. In the blood it is bound to the cell surface, especially the basophilic granulocytes, and is free in trace serum. Antigen-bound causes hypersensitivity and allergic reactions, and therefore elevated serum IgE levels. IgE antibodies created after first contact with a particular allergen are fixed on the surface of mast cells in the skin and mucous membranes. If the allergen that caused the production of IgE antibodies is again found in the circulation (after reintroducing incriminated food) it is bound to IgE antibodies fixed on the mast cell membrane. The result of the antigen-antibody reaction taking place on the surface of the mastocytes is their degradation whereby biologically active substances are released (histamine, leukotrienes and prostaglandins) The exact allergic diagnosis depends on the right choice of allergen for testing. Occasionally patients may develop symptoms caused by previously unidentified substances that may be new allergens, and patients should be screened to identify a new allergen. The most common allergens are pollen (from grass, weeds and trees), germs, domestic dust, animal fibers, mold, food, food additives and beverages, preservatives, insect poisons, UV rays. The most common form of allergy is pollen allergy, which is known as seasonal allergic rhinitis. Every tenth person has hay fever. Pollen allergy is a disease of the upper respiratory tract that occurs seasonally (from March to June) when pollen, grass and bark are found in the air. Typical symptoms are itching and tearing of the eyes, sneezing and secretion from the nose. Year-round rhinitis has the same symptoms as seasonal rhinitis and this allergy lasts a year. The most common causes of year-round rhinitis are: molds, animal fibers, germs.The aim of this survey is to show the importance of proving allergies by examining the specific circulating IgE antibodies that are generated as a response to the presence of antigens, to determine the categories of patients in whom the factors affecting an allergic reaction such as sex and age, to demonstrate which are the most common and which are the most intense allergic reactions that can be proven by measuring the specific IgE antibodies in the patient's serum.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Biljana Gorgeska
Date Deposited: 17 Dec 2019 11:31
Last Modified: 17 Dec 2019 11:31

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