Antitumor activity of resveratrol loaded solid lipid nanoparticles

Drakalska, Elena and Angelovska, Bistra and Sterjova, Marija (2019) Antitumor activity of resveratrol loaded solid lipid nanoparticles. In: 4th Congress of Pharmacists of Bosnia and Herzegovina, 10-13 Oct 2019.

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Resveratrol is identified as (3,5,4′-trihydroxy-trans-stilbene), classified as natural polyphenol consisting of two phenolic rings attached by methylene bridge. This active compound exhibited potent pleiotropic, antineoplastic activity without documented toxici-ty to normal cells. In addition, numerous studies reported that resveratrol, as most researched stilbene, possess numerous health-benefit properties, such as cardioprotective, antidiabetic, neu-roprotective and chemopreventive. Regretfully, clinical realization of resveratrol is restricted due to its poor aqueous solubility (0.05 mg/ml), degradation at physiological pH associated with ex-tremely low systemic bioavailability. An intriguing strategy to overcome these limitations is for-mulation of resveratrol-loaded nanoparticles such as solid-lipid nanoparticles as platforms for delivery to target tissues.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Elena Drakalska
Date Deposited: 17 Dec 2019 10:32
Last Modified: 17 Dec 2019 10:32

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