Antitumor activity of resveratrol loaded solid lipid nanoparticles

Drakalska, Elena and Angelovska, Bistra and Arev, Marija (2019) Antitumor activity of resveratrol loaded solid lipid nanoparticles. In: 4th Congress of Pharmacists of Bosnia and Herzegovina, 10-13 Oct 2019.

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Abstract

Resveratrol is identified as (3,5,4′-trihydroxy-trans-stilbene), classified as natural polyphenol consisting of two phenolic rings attached by methylene bridge. This active compound exhibited potent pleiotropic, antineoplastic activity without documented toxici-ty to normal cells. In addition, numerous studies reported that resveratrol, as most researched stilbene, possess numerous health-benefit properties, such as cardioprotective, antidiabetic, neu-roprotective and chemopreventive. Regretfully, clinical realization of resveratrol is restricted due to its poor aqueous solubility (0.05 mg/ml), degradation at physiological pH associated with ex-tremely low systemic bioavailability. An intriguing strategy to overcome these limitations is for-mulation of resveratrol-loaded nanoparticles such as solid-lipid nanoparticles as platforms for delivery to target tissues.

Item Type:	Conference or Workshop Item (Poster)
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Elena Drakalska
Date Deposited:	17 Dec 2019 10:32
Last Modified:	29 May 2023 10:15
URI:	https://eprints.ugd.edu.mk/id/eprint/23109

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