Gulaboski, Rubin (2019) Voltammetry application in measuring kinetics of drug-drug and the enzyme-substrate interactions. . (Unpublished)
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Application of Voltammetry for determination of kinetics of drug-drug interactions 2019 november.pdf Download (2MB) | Preview |
Abstract
We present in this work potential applications of voltammetric techniques to get insight into the kinetics of drug-drug interactions, and to kinetics of enzymatic reactions. The-so called catalytic regenerative mechanism is a powerful model to mimic the drug-drug and enzyme-substrate interactions under voltammetric conditions. Various theoretical models on this electrode mechanism provide means to to get access to kinetic and thermodynamic parameters relevant for many drug-drug and enzyme-substrate interactions. While we present plenty of simulated voltammograms, we give the readers simple approaches to access important physical parameters relevant to the chemical reactivity of lipophilic and hydrophilic drugs and enzymes.
| Item Type: | Teaching Resource |
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| Subjects: | Medical and Health Sciences > Basic medicine Natural sciences > Chemical sciences Natural sciences > Physical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Rubin Gulaboski |
| Date Deposited: | 25 Nov 2019 11:20 |
| Last Modified: | 25 Nov 2019 11:20 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/22941 |
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