Second generation platelet concentrate (platelet-rich fibrin) and it's application in oral surgery

Evrosimovska, Biljana and Veleska-Stefkovska, Daniela and Dimova, Cena and Menceva, Zaklina (2019) Second generation platelet concentrate (platelet-rich fibrin) and it's application in oral surgery. In: Nutricon 2019" Food Quality and Safety Health and Nutrition, 12-14 June 2019, Ohrid, Macedonia.

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The development of bioactive surgical additives, which are being used to regulate the inflammation and increase the speed of healing process, is one of the great challenges in oral surgery. Platelet-rich fibrin (PRF) is a second-generation platelet concentrate who was defined as an autologous leukocyte and PRF biomaterial, in which, platelets and leukocytes are collected with high efficiency such that the growth factors will able to release gradually during at least 1 week. The following article attempts to summarize our clinical cases regarding the technique of using PRF, focusing on its preparation, advantages of using it in oral surgery.
This technique requires neither anticoagulant nor bovine thrombin (nor any other gelling agent). It is nothing more than centrifuged blood without any addition.
The biologic effect of this fibrin matrix is: angiogenesis, immune control, harnessing the circulating stem cells, and wound protection by epithelial cover. The soft and bone tissue management in all our cases show process of neovascularization through the PRF clot and the epithelial covering development. In spite of the infectious and inflammatory statement of such sockets, rapid healing of the wound is observed without pain, dryness, or purulent complications.
PRF alone or in combination with other biomaterials seems to have several advantages and indications in oral surgery, due it is a minimally invasive technique with low risks and satisfactory results.

Keywords: Platelet-rich fibrin, blood platelet, bone regeneration, soft tissue regeneration.

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Cena Dimova
Date Deposited: 10 Sep 2019 08:32
Last Modified: 10 Sep 2019 08:32

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