Impact of foods and dietary supplements containing hydroxycinnamic acids on cardiometabolic biomarkers: A systematic review to explore inter-individual variability

Martini, Daniela and Chiavaroli, Laura and González-Sarrías, Antonio and Bresciani , Letizia and Palma-Duran, Susana A. and Dall’Asta, Margherita and Deligiannidou, Georgia-Eirini and Massaro, Marika and Scoditti, Egeria and Combet, Emilie and Maksimova, Viktorija and Urpi-Sarda, Mireia and Kontogiorgis, Christos A. and Andrés-Lacueva, Cristina and Gibney, Eileen R. and Del Rio, Daniele and Morand, Christine and Garcia-Aloy, Mar and Rodriguez-Mateos, Ana and Mena, Pedro (2019) Impact of foods and dietary supplements containing hydroxycinnamic acids on cardiometabolic biomarkers: A systematic review to explore inter-individual variability. Nutrients, 11 (8). pp. 1805-1847. ISSN 2072-6643

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Abstract

Plant-based diets rich in bioactive compounds such as polyphenols have been shown to
positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the
response to these bioactives may affect the findings. This systematic review aimed to summarize
findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic
acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed
and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts
on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria.
Comparisons were made between RCTs, including assessments based on population health status.
Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to
HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall
effectiveness, which was also found in studies where specific subgroup analyses were performed.
Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although
future studies in these populations are needed, including those on other potential determinants of
inter-individual variability. PROSPERO, registration number CRD42016050790.

Item Type:	Article
Impact Factor Value:	4.171
Subjects:	Medical and Health Sciences > Basic medicine Natural sciences > Biological sciences Natural sciences > Chemical sciences Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Viktorija Maksimova
Date Deposited:	21 Jan 2020 14:16
Last Modified:	21 Jan 2020 14:16
URI:	https://eprints.ugd.edu.mk/id/eprint/22413

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