Mogućnosti i izazovi alternativnih strategija i nanotehnologije u kontroli antimikrobnih rezistencija i infekcija Possibilities and challenges of alternative strategies and nanotechnology in control of antimicrobial resistance and infections

Infection diseases caused by antimicrobial resistant bacteria (AMR) present major global health concern and a great challenge for science and medicine. Over 700 000 deaths worldwide (33.000 in Europe), including 214 000 neonatal sepsis deaths, are caused by AMR each year. AMR may kill 10 million people per year, by 2050 unless successful action is taken. People’s lives depends on effectiveness of antibiotics. WHO priority pathogens list includes: Critical priority: Acinetobacter baumannii, carbapenem-resistant; Pseudomonas aeruginosa, carbapenem-resistant; Enterobacteriaceae, carbapenem-resistant, ESBL-producing; High priority: Enterococcus faecium, vancomycin-resistant; Staphylococcus aureus, methicillin-resistant, vancomycin-intermediate and resistant; Helicobacter pylori, clarithromycin-resistant; Campylobacter spp., fluoroquinolone-resistant; Salmonellae, fluoroquinolone-resistant; Neisseria gonorrhoeae, cephalosporin-resistant, fluoroquinolone-resistant; Medium priority: Streptococcus pneumoniae, penicillin-non-susceptible; Haemophilus influenzae, ampicillin-resistant; Shigella spp., fluoroquinolone-resistant.