Biomonitoring of lipids, enzymes, and creatine kinase in patients with statins therapy

Velickova, Nevenka and Nateva, Marina and Stojanova, Slagana (2019) Biomonitoring of lipids, enzymes, and creatine kinase in patients with statins therapy. In: 5th International Conference on Sustainable Development (ICSD) , 17-21 Apr 2019, Belgrade, Serbia.

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Introduction: Treatment with statins in patients with dyslipidaemia causes an effective and rapid reduction of the concentration of cholesterol in the blood, on the one hand while on the other hand it causes pathophysiological changes in the tissues. For exemple, in muscle tissue (increasing the serum creatine kinase values), in hepatic tissue (increasing the values of serum transaminases), and other cytological changes as important biomarkers for the cytotoxic effect of statins. Scientific studies indicate that statins (atorvastatin, simvastatin, pravastatin, cerivastatin, fluvastatin and rosuvastatin) have cytotoxic effects in the organism, if are used in high doses and for long time. The aim of the study is to conduct biomonitoring of the cytotoxic effect of statins in patients with dyslipidemia. Material and methods: The subjects are patients with confirmed dyslipidemia, with increased concentration of cholesterol in the blood and on therapy with statins, in order to reduce the risk of cardiovascular diseases. The patients were divided into groups according to their age and type of the statins therapy. Results: With biomonitoring of lipids, enzymes and creatine kinase, we evaluated the cytotoxicity of statins in different patients according to their age, duration of therapy, sensitivity and other physiological parameters. Conclusions: We confirm the scientific knowledge that statins have a cytotoxic effect if are administered in the body for a long time, especially in high dose.

Keywords: biomonitoring, statins, enzimes, cytotoxic effect

Item Type: Conference or Workshop Item (Poster)
Subjects: Medical and Health Sciences > Basic medicine
Divisions: Faculty of Medical Science
Depositing User: Nevenka Velickova
Date Deposited: 13 Aug 2019 09:10
Last Modified: 13 Aug 2019 09:10

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