Medicinal plants and their effects against free radical induced changes in the cell

Maksimova, Viktorija (2019) Medicinal plants and their effects against free radical induced changes in the cell. In: Second Training Course: Methods for genotoxicity detection and evaluation, 12-16 May 2019, Stip, Republic of North Macedonia.

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Pharmacokinetic and pharmacodinamic variability on the effects of certain plant extract v.s pure phytochemical constituent is more than possible. Herbal extracts are particularly interesting because we can not strictly predict the synergism or antagonism of all the phytochemicals present in the extracts.
In example,capsaicin it self has shown low antioxidant effect and important cytotoxicity. As expected, the antioxidant effects of capsicum extracts (containig capsiaicin, quercetin, luteolin, B-carotens, ascorbic acid) have shown a higher antioxidant potential, but its cytotoxic properties were lost.During physiological and pathological processes, ROS and RNS in cell can act as secondary messengers and control gene expression, apoptosis, cell growth, cell cycle, cell adhesion, chemotaxis, protein-protein interactions and enzymatic functions, Ca2+ and redox homeostasis. ROS and Ca2+ are two cross-talking secondary messengers in numerous cellular processes.

Interactions between Ca2+ and ROS signaling systems can be both stimulatory and inhibitory.
Therfore, there is a delicate balance between the beneficial and detrimental consequences of Ca2+ and ROS regarding the mitochondrial function. Capsaicin as a TRPV1 receptor (Ca2+ –channel) agonist and a molecule with antioxidant potential was observed in one of our studies.
As a conclusion this study confirmed high antioxidative potential of the co-extracted compounds present in the ethanolic extracts of Capsicum, and they could have an antagonistic effect to capsaicin cytotoxic mechanism. This hypothesis enforced us to consider that the synergistic antioxidative effect of the complex composition of hot pepper fruits is responsible that ethanolic Capsicum extracts have not shown cytotoxic activity, beside its high concentration of capsaicin.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Viktorija Maksimova
Date Deposited: 06 Jun 2019 12:53
Last Modified: 06 Jun 2019 12:53

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