Tuning calcium responses

Bogeski, Ivan and Hoth, Markus (2010) Tuning calcium responses. Nature Immunology, 11 (6). p. 469. ISSN doi:10.10.1126/scisignal.2000672

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How calcium signaling, which triggers key functional responses during
lymphocyte activation, is influenced by reactive oxygen species is
unclear. In Science Signaling, Niemeyer and colleagues show that hydrogen
peroxide (H2O2) can oxidize and inhibit the stores-operated calcium
channel protein ORAI1 but not the related proteins ORAI2 or ORAI3.
This difference in redox sensitivity is due to Cys195 in an extracellular
loop of ORAI1 (but absent from the other ORAI proteins) that becomes
disulfide-linked after H2O2 exposure. This modification decreases the
ORAI-dependent inward Ca2+ flux triggered by release of endoplasmic
reticulum stores and activation of the Ca2+ sensor STIM1. Effector T cells
are less sensitive than naive T cells to H2O2 oxidation, as expression of
ORAI3 is higher in effector cells. Knockdown of ORAI3 in effector T cells
increases their sensitivity to oxidizing environments, which leads to lower
viability and less interleukin 2 (IL-2) production. How Orai3 expression
is upregulated in effector cells remains unknown, but this response is
probably critical for effector function at sites of inflammation.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Medical and Health Sciences > Health sciences
Divisions: Faculty of Medical Science
Depositing User: Ivan Bogeski
Date Deposited: 27 Nov 2012 12:19
Last Modified: 27 Nov 2012 12:19
URI: https://eprints.ugd.edu.mk/id/eprint/2209

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