Janevik-Ivanovska, Emilija (2018) Preclinical studies in development of therapeutic radiopharmaceuticals - the critical approach for successful clinical application. In: 7th Balkan Congress of Nuclear Medicine, 9-12 May 2018, Sarajevo, BiH.
Preview |
Text
BSMN SARAEVO 2018 E.Janevik 1.pdf Download (7MB) | Preview |
Preview |
Text
Book of abstracts BCNM Sarajevo.pdf Download (816kB) | Preview |
Abstract
The goal of this presentation is to discuss how development of therapeutic radiopharmaceuticals - the critical approach for successful clinical application.
The most important critters before to start preclinical investigation, are:
• High target activity and concentration including affinity and specificity, absence of biological barriers (i. e. endothelium, blood brain barrier,...) and stable labeling of compound
• Low background activity, that comprehend non- specific accumulation, circulating or interstitial activity and renal or hepatic elimination
• Signal amplification as cell trapping, enzymatic conversion and “Reporter” radioactive molecules. Preclinical studies for therapeutic radiopharmaceuticals
should be designed to assess:
• The in vivo stability of the radionuclide complex • The animal biodistribution of the radionuclide • The potential chemical toxicity
• The radiation exposure of tissues.
Data required to establish preclinical safety of radiopharmaceuticals include
• In vitro target/receptor profiling including pharmacodynamics
• Pharmacokinetics
• Potential chemical toxicity including antigenicity
• Radiation exposure of tissues
• Late radiation toxicity
• The dose evoking pharmacologic activity or antigenicity, and
• The minimum radioactivity dose needed for satisfactory imaging.
| Item Type: | Conference or Workshop Item (Lecture) |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Emilija Janevik |
| Date Deposited: | 06 Feb 2019 08:05 |
| Last Modified: | 06 Feb 2019 08:05 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/21489 |
Actions (login required)
 |
View Item |