The role of radiopharmaceuticals in individualized diagnostic and therapy

Arev, Marija and Janevik-Ivanovska, Emilija and Smilkov, Katarina and Darkovska-Serafimovska, Marija (2018) The role of radiopharmaceuticals in individualized diagnostic and therapy. In: 3rd International Scientific Conference of the Faculty of Medical Science, 8-10 Nov 2018, Ohrid, Macedonija.

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The patient outcomes resulting from the use of radiopharmaceuticals, have demonstrated the value of these pharmaceuticals making molecular processes in the body visible to detect disease processes early and enable a targeted treatment.
Examination techniques employed such as positron emission tomography (PET) or single-photon emission computer tomography (SPECT) are also able to illustrate tumor metabolism, that being a tumor’s response to a specific treatment showing the function of individual organs by illustrating their metabolism.
The greatest challenge associated with the design of novel radiolabeled compounds (radiopharmaceutical) is the development of the molecule for selective tissue targeting and that meet the therapeutic requirements with an acceptable toxicity.
Using diagnostic radiopharmaceuticals in multi-modality imaging, as a combination of nuclear and radiology (CT, MRI), is beginning to gain widespread application. It offers not only more accurate diagnosis, but also facilitates personalized therapy and helps a better understanding of the underlying pathological processes.
For the other hand, ideal therapeutic radiopharmaceuticals should locate at the tumor site, producing minimal or tolerable radiation damage to normal surrounding tissues.
The design of better radiopharmaceuticals, requires optimization between in vivo targeting of the tissue (tumor) and the clearance of radioactivity from non-target radiosensitive tissues as well as the decay properties of the radionuclide.

Keywords: Radiopharmaceutical, SPECT, PET, Therapy, Diagnosis.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Medical and Health Sciences > Basic medicine
Divisions: Faculty of Medical Science
Depositing User: Marija Arev
Date Deposited: 18 Dec 2018 12:47
Last Modified: 25 May 2023 11:02

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