Beneficial effects of Lactobacillus sp. against Streptococcus mutans

Stojanov, Spase and Gjorgieva Ackova, Darinka and Smilkov, Katarina (2018) Beneficial effects of Lactobacillus sp. against Streptococcus mutans. In: First International Students Congress in Dental Medicine - 2018, 28-29 March 2018, Stip, Macedonia.

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Probiotics are known for their beneficial effects to health and their action is often linked to the GI health. Oral health is owed to the ecological balance in the oral cavity, still considering the pathogen Streptococcus mutans primarily responsible for initiating dental caries and tooth decay, as well as periodontal disease. Studies have shown that different Lactobacillus species can exert beneficial effects in oral health as well as GI health.
The main goal of this research is to examine the reported positive effect of Lactobacillus against oral diseases, caused by S. mutans.
Several studies have shown that co-culture of S. mutans with different Lactobacillus strains significantly reduced the numbers of S. mutans and total bacteria in the mixed biofilm cultures compared with the control group. Different Lactobacillus strains have varying inhibition activity against S. mutans. In one study, it has been shown that Lactobacillus acidophilus has a reducing power to gene expression, and reduced the expression of the genes GtfB and LuxS by 60-80%. Another study showed that the lipoteichonic acid of the Lactobacillus plantarium is responsible for the antibacterial effect of the probiotics against oral pathogens. Namely, the biofilm formation from S. mutans in the presence of lipoteichonic acid was evaluated by using confocal laser scanning microscopy and scanning electron microscopy. The results of the study showed that S. mutans biofilm formation and aggregation were inhibited by lipoteichonic acid in a dose-dependent manner.
These results present potential of new concept of prevention/treatment in S. mutans - caused oral diseases.

Item Type: Conference or Workshop Item (Poster)
Subjects: Natural sciences > Biological sciences
Medical and Health Sciences > Health biotechnology
Medical and Health Sciences > Health sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Katarina Smilkov
Date Deposited: 16 Oct 2018 07:53
Last Modified: 16 Oct 2018 07:53

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