The emerging role of copper-64 radiopharmaceuticals as cancer theranostics

Boschi, Alessandra and Martini, Petra and Janevik-Ivanovska, Emilija and Duatti, Adriano (2018) The emerging role of copper-64 radiopharmaceuticals as cancer theranostics. Drug Discovery Today, 23 (8). pp. 1489-1501. ISSN 1359-6446

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Abstract

Copper radionuclides are rapidly emerging as potential diagnostic and therapeutic tools in oncology, particularly 64Cu-radiopharmaceuticals for targeting neuroendocrine, prostate, and hypoxic tumors. Unexpectedly, experimental results are also revealing the impressive biological behavior of simple [64Cu2+] ions. For example, it has been demonstrated that administration of ionic [64Cu2+] in physiological solution allows the selective targeting of a variety of malignancies. These remarkable biological properties appear to be crucially linked to the natural role of copper ions in cell proliferation. Here, we review the current status of 64Cu-radiopharmaceuticals in molecular imaging and cancer therapy.

Item Type:	Article
Additional Information:	additional contact person Adriano Duatti dta@unfe.it
Subjects:	Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health biotechnology
Divisions:	Faculty of Medical Science
Depositing User:	Emilija Janevik
Date Deposited:	13 Aug 2018 09:45
Last Modified:	13 Aug 2018 09:45
URI:	https://eprints.ugd.edu.mk/id/eprint/20288

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