The impact of antioxidants on the cytotoxic properties of capsaicin

Maksimova, Viktorija and Koleva Gudeva, Liljana and Gulaboski, Rubin (2017) The impact of antioxidants on the cytotoxic properties of capsaicin. In: 3rd International Conference on Natural Product Utilization: From Plants to Pharmacy Shelf, 18-21 Oct 2017, Bansko, Bulgaria.

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Many studies revealed the cytotoxic properties of capsaicin on different types of cancer cells by discussing the mechanism of its toxicity. This study comprises the impact of antioxidants on the cytotoxic properties of capsaicin and therefore confirming or dismissing some of the thesis given previously.
The aim of this review is to examine the influence of a combination of a few common antioxidants, which possess particularly high antioxidative potential, as a reason to inhibit the cytotoxic activity of pure capsaicin. This is due to the synergistic antioxidative effect of capsaicin and other co-extracted bioactive compounds (vitamin C, vitamin E and some flavonoids). In a previous study, we have shown that Capsicum extracts did not showed cytotoxic activity on neuroblastoma cells, beside the cytotoxic properties of capsaicin, itself, at concentrations 0.5 mmol/L to 2.1 mmol/L. As shown in the literature, one of the mechanisms of capsaicin cytotoxicity that has been proposed support the production of reactive oxygen species on cellular level. This leads to disruption of mitochondrial membrane potential, activation of caspase-3 activity and successive apoptosis. We assumed that this phenomenon of synergism on the antioxidative effect between capsaicin and other bioactive compounds present in the extracts could be a possible reason for inhibition of the cytotoxic effect of capsaicin.
This data should stress out the importance of a balanced intake of antioxidants while using a cytotoxic agent, which acts as a prooxidnat in cancer cells.

Item Type: Conference or Workshop Item (Poster)
Subjects: Natural sciences > Biological sciences
Natural sciences > Chemical sciences
Medical and Health Sciences > Other medical sciences
Divisions: Faculty of Medical Science
Depositing User: Viktorija Maksimova
Date Deposited: 09 Nov 2017 11:17
Last Modified: 09 Nov 2017 11:19

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