Drakalska, Elena and Momekova, Denitsa and Rangelov, Stanislav and Lambov, Nikolay and Angelovska, Bistra (2017) Hybrid pH-sensitive nanoparticles as platforms for delivery of curcumin. In: 17th International Symposium and Summer School on Bioanalysis, 02-08 July 2017, Ohrid, R. Macedonia.
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Abstract
Curcumin, the yellow powder derived from the plant Curcuma Longa, exhibited
numerous therapeutic applications against wide range of chronic diseases such as
diabetes, pancreatitis, arthritis, neurodegenerative diseases and various types of cancer.
The mechanism of antineoplastic activity of curcumin is through modulation of cell
signaling pathways, mainly blockage of nuclear factor kappa B (NF-κB) activation and
induction of apoptosis in different types of human cancer cell lines, associated with
excellent safety profile. Unfortunately, the tremendous therapeutic potential of
curcumin as a chemopreventive, antineoplastic and chemosensitizing agent has failed to
progress towards clinical development and commercialization due to its unfavorable
physicochemical properties, low aqueous solubility, chemical instability, and
pharmacokinetics. An intriguing strategy to overcome these limitations is the design of
nanosized vehicles for efficient delivery of curcumin. The present contribution is
focused on elaboration of hybrid pH-sensitive liposomes based on
dipalmitoylphosphathydilcholine:cholesterol (DPPC:CHOL) and a pH-sensitive
poly(isoprene-b-acrylic acid) (pI-pAA), whereby curcumin is entrapped as a free drug
and as a water soluble inclusion complex with polyoxyethylated calix[4]arene, which
allows the drug to occupy both the phospholipid membranes and the aqueous core of
liposomes. Nanoparticles were characterized by DLS, cryo-TEM, curcumin
encapsulation efficacy and in vitro release as a function of pH.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elena Drakalska |
| Date Deposited: | 31 Aug 2017 10:04 |
| Last Modified: | 31 Aug 2017 10:04 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/18133 |
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