Sleep apnea and sleep fragmentation contribute to brain aging

Richter, Kneginja and Miloseva, Lence and Niklewski, Günter (2016) Sleep apnea and sleep fragmentation contribute to brain aging. EPMA Journal, Suppl1 (7). A61. ISSN 1878-5085

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Sleep apnea is a frequent disturbance with prevalence of 3-4% in adult man (Young, 1993, Shepertycky, 2005), and is 2-9 times more prevalent in men than women (Bozkurt 2008). The most prominent Symptoms of Sleep Apnoea are intermittent breaks of breathing in the night (Apnoea) which causes general hypoxia and daily sleepiness. The Diagnosis of Sleep Apnea can be made by Polygraphy and/or Polysomnography recording in Sleep labor according to the following criteria: more than 10 Apneas in one hour of sleep , each with duration longer than 10 seconds. The reason for cognitive decline in Patients with Sleep Apnea is the intermittent Hypoxia which causes disturbances of memory, attention and learning (Wolkove 2007, Spira 2008, Ancoli-Israel 1991, Cynthia 2002). According to actually studies, Hypoxia causes cellular damage of left hippocampus area which is one of the key brain areas for the cognition and memory (Torelli 2011, Paul 2002, Mary 2003).

But not only Hypoxia as result of apneas can induce cognitive decline, also the fragmentation of the sleep by frequent awakening caused by intermittent apneas impairs the consolidation of the memory especially in the REM (Rapid eye movement) sleep stage of the sleep. Sleep apnea and sleep fragmentation can be significant factors for brain aging causing severe disturbances of the cognition through hypoxia of the brain and Hyperarousals (stress). Early Prevention of Sleep Apnea can probably protect from early brain aging.
Keywords: Brain Aging, Sleep Apnea, Sleep disturbances, Sleep Fragmentation

Item Type: Article
Subjects: Medical and Health Sciences > Clinical medicine
Divisions: Faculty of Medical Science
Depositing User: Lence Miloseva
Date Deposited: 23 May 2017 11:30
Last Modified: 23 May 2017 11:30

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