Preparation and characterization of curcumin loaded hybrid pH-sensitive liposomes

Drakalska, Elena and Momekova, Denitsa and Bodurova, Desislava and Rangelov, Stanislav and Lambov, Nikolay (2016) Preparation and characterization of curcumin loaded hybrid pH-sensitive liposomes. In: 6th Congress of pharmacy with international participation, 13-16 Oct 2016, Sandanski, Bulgaria.

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Abstract

Curcumin is a polyphenol compound with pleiotropic antineoplastic activity and low toxicity to normal cells. The clinical realization of its potential is limited due to its unfavorable physicochemical and pharmacokinetic properties. A possible approach to overcome these limitations is the encapsulation of curcumin into nanocarriers. The present contribution is focused on elaboration of hybrid pH-sensitive liposomes based on dipalmitoylphosphathydilcholine:cholesterol (DPPC:CHOL) and a pH-sensitive poly(isoprene-b-acrylic acid) (pI-pAA), whereby curcumin is entrapped as a free drug and as a water soluble inclusion complex with polyoxyethylated calix[4]arene, which allows the drug to occupy both the phospholipid membranes and the aqueous core of liposomes.

Item Type:	Conference or Workshop Item (Lecture)
Subjects:	Medical and Health Sciences > Other medical sciences
Divisions:	Faculty of Medical Science
Depositing User:	Elena Drakalska
Date Deposited:	25 Oct 2016 10:26
Last Modified:	25 Oct 2016 10:26
URI:	https://eprints.ugd.edu.mk/id/eprint/16453

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