Drakalska, Elena and Momekova, Denitsa and Rangelov, Stanislav and Lambov, Nikolay (2016) Curcumin loaded hybrid pH-sensitive liposomes-preparation and characterization. In: From Molecules to Functionalized Materials, Module “Optical and Electronic Devices“, 1-5 Sept 2016, Ohrid, Macedonia.
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Abstract
therapeutic applications against wide range of chronic diseases such as diabetes, pancreatitis, arthritis, neurodegenerative diseases and various types of cancer without toxicity to normal cells. Despite the numerous advantages, clinical realization of curcumin‘s potential has been limited due to its poor aqueous solubility (11ng/ml) and very low systemic bioavailability. An intriguing strategy to overcome these limitations is the design of nanosized drug delivery systems. Present study reports the preparation and characterization of hybrid pH-sensitive liposomal nanoparticles as platforms for delivery of curcumin. The pH-sensitive liposomes based on dipalmitoylphosphathydilcholine:cholesterol (DPPC:CHOL) and a pH-sensitive poly(isoprene-b-acrylic acid) (pI-pAA) were prepared by lipid film hydration method and extrusion, whereby curcumin is entrapped as a free drug and as a water soluble inclusion complex with polyoxyethylated calix[4]arene.Physicochemical characteristics of the nanoparticles (size, size distribution and zeta potential) were evaluated by DLS and the results revealed particles of app.180 nm with monomodal distribution (PDI below 0.2) and zeta potential of – 20 mV suitable for systemic application. Hybrid pH-sensitive liposomes showed significantly improved drug release profile. Formulated curcumin also presented superior cytotoxic activity in comparison with the free drug. These findings give us a reason to conclude thatthe hybrid pH-sensitive liposomal nanoparticles are promising platforms for curcumin
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Subjects: | Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elena Drakalska |
| Date Deposited: | 29 Sep 2016 09:53 |
| Last Modified: | 29 Sep 2016 09:53 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/16301 |
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