Inter-individual variability in response to the intake of flavonols on blood lipid levels: a meta-analysis of randomized controlled human trials

Menezes, Regina and Rodriguez-Mateos, Ana and Kaltsatou, Antonia and González-Sarrías, Antonio and Greyling, Arno and Giannaki, Christoforos and Andres-Lacueva, Cristina and Gibney, Eileen R and Dumont, Julie and Schär, Manuel and Garcia-Aloy, Mar and Durán, Susana and Ruskovska, Tatjana and Maksimova, Viktorija and Combet, Emilie and Pinto, Paula (2016) Inter-individual variability in response to the intake of flavonols on blood lipid levels: a meta-analysis of randomized controlled human trials. In: The First International Conference on Food Bioactives and Health, 13-15 Sept 2016, Norwich, UK.

[thumbnail of FBHC2016 Norwich2.pdf]
FBHC2016 Norwich2.pdf

Download (382kB) | Preview
[thumbnail of FinalBioactives&Health_Flavonols_abstract.pdf]

Download (123kB) | Preview


Cardiovascular diseases (CVD) continue to be the leading cause of morbidity and mortality in most developed countries [1]. Several epidemiological studies have linked flavonols with decreased risk of stroke [2] and CVD [3], whilst human intervention studies have shown improvements in several biomarkers of CVD risk after flavonol consumption [4]. However, some heterogeneity in the individual physiological responses to the consumption of these compounds has been identified. For example, age and stage of hypertension seem to be important factors influencing the blood pressure lowering effect of quercetin [5, 6]. This meta-analysis aims to analyse the effect of flavanol intake on blood lipids, one of the major biomarkers of CVD risk, and factors affecting the inter-individual variability.
A systematic search was conducted in PubMed, Web of Science, Scopus and trial registry platforms. Only human randomized controlled trials with measured cardiometabolic outcomes were selected for data extraction of the measured outcomes, individual factors of the participants, characteristics of the study, and study quality. From 671 screened references, 19 studies were selected for data extraction and 16 studies were used for meta-analysis on total cholesterol, LDL, HDL and triacylglycerides (TAG). Inter-individual variability was assessed by subgroup analysis on BMI, age, sex, country and health status. Estimated intervention/control standardized mean differences suggested that consumption of flavonols was associated with significant reductions in total cholesterol (-0.180 mmol/L, 95% CI -0.307, -0.053), LDL (-0.219 mmol/L, 95% CI -0.350, -0.088) and TAG (-0.280 mmol/L, 95% CI -0.408, -0.151) and a significant increase in HDL (0.235 mmol/L, 95% CI 0.104, 0.365). Subgroup analysis showed a more pronounced effect in Asian countries and in participants with normal baseline lipid levels, compared to borderline and high baseline values. Results suggest that ethnicity and health status may influence the effect of flavonol intake on blood lipid levels.

Item Type: Conference or Workshop Item (Lecture)
Subjects: Medical and Health Sciences > Clinical medicine
Medical and Health Sciences > Health sciences
Agricultural Sciences > Other agricultural sciences
Divisions: Faculty of Medical Science
Depositing User: Tatjana Ruskovska
Date Deposited: 29 Sep 2016 10:34
Last Modified: 29 Sep 2016 10:34

Actions (login required)

View Item View Item