Zisovska, Elizabeta and Trajkova, Kornelija (2016) Impaired Metabolism Induced By Perinatal Hypoxia. International Journal of Innovative Research in Medical Sciences (IJIRMS), 1 (6). pp. 246-250. ISSN (Online): 2455-8737
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Abstract
Perinatal hypoxia induces disturbances in glucose metabolism. In anaerobic environment, high level of
lactate production persists, causing endothelial damage and deleterious effect on the brain. The outcome depends on
the brain capacity to utilize lactate and ketones as an alternative energy source to glucose. There isn't evidence that
depriving infants of glucose after hypoxia is neuroprotective. The aim of our study was to present the results of blood
investigation for blood sugar level (BSL), lactate level (LL), and to assess the correlation between these markers and
severity of Hypoxic-ischemic encephalopathy (HIE). Material: asphyxiated newborns born at Obstetric&Gynecology
Clinic in Macedonia. Methods: clinical, biochemical, statistical. Results: at first sight we got almost normal value of
BSL (mean value in healthy full-term infants was 2,8 mmol/l, in examined group 2,7 mmol/l), but deep analysis of
distribution showed three-modal curve: 33% of them had normal value (3,1 mmol/l), 43% of the babies were
hypoglycemic (BSL 1,3 mmol/l) and 24% were hyperglycemic with BSL of 4,8 mmol/l. The LL had very concordant
distribution: in hypoglycemic infants LL was much lower than normal values (<0,9 micromol/l compared to normal
value 1,2-1,8 micromol/l), similar in normoglycemic infants (LL was 1,0 micromol/l), in hyperglycemic the LL
increased significantly to 2,8 micromol/l,. The Spearman coefficient of correlation showed moderate level of
correlation between LL and severity of HIE (r=0,65). Conclusion: perinatal hypoxia is still important cause of brain
damage, and the management of hypoxic baby includes careful maintenance of glycaemia and other homeostatic
parameters.
Keywords: newborn, hypoxia, blood sugar, lactates.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elizabeta Zisovska |
| Date Deposited: | 05 Sep 2016 13:52 |
| Last Modified: | 05 Sep 2016 13:52 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/16152 |
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