Redox chemistry of coenzyme Q—a short overview of the voltammetric features

Gulaboski, Rubin and Markovski, Velo and Zhu, Jihe (2016) Redox chemistry of coenzyme Q—a short overview of the voltammetric features. Journal of Solid State Electrochemistry, 20. pp. 1-10. ISSN 1432-8488

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Quinones constitute a big family of organic redox active compounds that are overwhelmingly involved in important physiological processes. The most important members in the class of quinones are, indeed, the plastoquinones and the coenzyme Q (CoQ) derivatives. Voltammetry of coenzyme Q family members attracts significant attention since 50 years ago. In this work, we refer to some of the most important voltammetric features of coenzyme Qs studied in aprotic and in aqueous media. While the redox chemistry of coenzyme Q members in non-aqueous aprotic organic solvents can be described by two consecutive one-electron transfer steps, more complex situation exists in the voltammetryofcoenzymeQsperformedinaqueousmedia.Althoughit has been claimed for a while that the voltammetric processes ofcoenzymeQsinaqueoussolutionsproceedviaformationof semiquinone radical intermediate species, it has been recently proven that this can be not completely true. Intensive voltammetric and spectroscopic studies of coenzyme Q systems in buffered and non-buffered aqueous media revealed that hydrogen bonding between electrochemically created CoQ species and the water molecules plays an important role instabilizingelectrochemicallygeneratedspeciesofthesesystems.Wealsopayattentiontotheamazingredoxchemistryof coenzyme Qs in strong alkaline media, while we refer to the chemical features of novel coenzyme Q derivatives obtained under such conditions. Hints are presented about the
antioxidant capacity of some of the novel hydroxylated coenzymeQsystems.Also,thepossibilityofthesesystemstobind and transfer earth-alkaline cations across biomimetic membranes is shortly elaborated. In the end, we refer to some relevant theoretical works that describe closely the voltammetric behavior of various coenzyme Q systems. We believe that this short review will contribute towards better understanding of the amazing chemistry of coenzyme Q derivatives.

Item Type: Article
Subjects: Medical and Health Sciences > Basic medicine
Natural sciences > Chemical sciences
Divisions: Faculty of Medical Science
Depositing User: Rubin Gulaboski
Date Deposited: 06 Jun 2016 09:48
Last Modified: 06 Jun 2016 09:50

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