Zisovska, Elizabeta and Gurzanova-Dunev, Liljana and Trajkova, Kornelija (2016) Brain damage and enzyme activity following birth asphyxia. Sylwan Journal. English Edition (Sec 2), 160 (2). pp. 1-19. ISSN 0039-7660
Full text not available from this repository.Abstract
Identification of newborns with brain damage following birth asphyxia should enable neuroprotective interventions and limit the extent of injury.This study aimed to show the early postnatal dynamics of the catalytic activity of creatine-kinase brain isoenzyme (CK-BB) in serum of the full-term newborns and its value as predictor of the severity of brain damage (Hypoxic-ischemic encephalopathy, HIE). Material: newborns born at the Gyn&Obs; Clinic in Skopje, Macedonia investigated by clinical, biochemical and statistical methods. Results: 92/5494 full term newborns met the eligible criteria, survived birth asphyxia. Performing clinical-neurological Sarnat&Sarnat; classification, 18.5% newborns had no signs of HIE, and 81.5% had some level of HIE. The values of the catalytic activity of CK-BB had specific course in all three intervals between the control and investigated group (p<0.05), and within the subgroups. Overall mean value CK-BB in the control group was 31.3 U/l versus 204.2 U/l in the examined group. The Spearman coefficient of correlation (R) was very high for the value of CK-BB and correspondent stage of HIE. Conclusion: CK-BB is highly predictive in assessing the severity of HIE, and can serve as early indicator for the brain damage and short term outcome of the asphyxiated full-term neonates when measured soon after birth.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Elizabeta Zisovska |
| Date Deposited: | 23 Mar 2016 10:09 |
| Last Modified: | 23 Mar 2016 10:09 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/15612 |
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