Nikolovski, Robert and Denchovska, Kristina and Mladenovski, Goran and Markovski, Velo (2015) Analysis of the Pap test results by age groups in the area of Kriva Palanka. In: International Symposium at Faculty of Medical Sciences “Current achievements and future perspectives in medical and biomedical research”, 24 Nov 2015, Stip, Macedonia.
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Abstract
Introduction: Pap testis a method of early detecting cancerous processes in the uterus.The first Pap test in Kriva Palanka was made in 1974. It was performed by doctors of General Medicine, till the opening of the Gynecological - Obstetric Department.
Purposes: The aim of this work is to make comparison between positive results of Pap test in different age groups.
Materials and methods: For this purpose it is used an epidemiological method with a retrospectively study. Two age groups are being analyzed. In the first group there are femalepatients at the age of 49 to 60 years and the second group is consisted of female patients at the age of 24 to 35 years. The screening of the first group was made in 2014 while the screening of the second group in 2015. The data of only first 9 months for both years are being used for the analysis because the year 2015 hasn’t finished yet. The data are from Gynecological - Obstetric Department in Kriva Palanka.
Results and discussion: From January 1st 2014 to December 30th 2014, the total number of female patients that came for screening of detecting cancer of the uterus was 493, elder group in age of 49 to 60 from which 397 came in the first 9 months. In the second age group, 24 to 35 years, there were 418 female patients that came in the first 9 months. The study analyzed the following findings: ASC-US-atypicalsqamous cells of undetermined significance., ASC-H (atypical squamous cells-high grade lesion); Endo CIN1 (endocervical-cervical intra epithelial neoplasia1); endo CIN2 (endocervical-cervical intra epithelial neoplasia2); AGC (atypical glandular cells); CIN 1 (cervical intra epithelial neoplasia 1); 2 CIN (cervical intra epithelial neoplasia 2); 3 CIN (cervical intra epithelial neoplasia 3); CIS (carcinoma in situ). All mentioned findings are considered high risk and without proper treatment after a certain period will lead to development of malignant neoplasm. The samples from the patients are given to the analysis laboratory at PHI “CytoLab” - Kumanovo. The typology of confirmed HPV was made in the laboratory of MASA(Macedonian Academy of Sciences and Arts).ASC-US is found at 15 femalepatients in the elder group, and in 7 cases in the younger group; ASC-H is found in 2 cases in the elder group. In the younger group there were no such findings. There was 1 finding of Endo CIN 1, but in the elder group, as the case with Endo CIN 2 – only 1 finding in the elder group. In the elder group, HPV was diagnosed in 23 cases, and in the younger group it is diagnosed in 11 cases. In the elder group CIN 1 is diagnosed in 45 cases over against younger group-diagnosed in 13 cases.In the elder group CIN 2 was diagnosed in 4 cases contrasted with 1 case diagnosed in the younger group.CIN 3 was found in 1 case in each age group. In the elder group AGC was found in 8 cases unlike the younger group - only in 1 case. There were 2 cases with findings of CIS in the elder age group and none in the younger group. According to the results, the total amount of positive results in the elder group add up to 102 from among 397 examined femalepatients (25,7%), and in the younger group 35 from examined 418 femalepatients (8,4%). In the Republic of Macedonia the screening programme is established on April 1st2012.
Conclusion: In accordance with the positive Pap tests, it is determined statistically significant difference between first and second age group of the patients. In the elderly group of patients there isan increased number of diagnosed high-risk premalignant lesions, unlike the younger group where this number is significantly smaller. There is significant increase in the number of patients undergoing a proven high-risk HPV in the elder population. Based on the analysis results we can conclude that it is particularly important initiation of timely screening in the younger population so early detection, timely treatment and prevention of progression to malignancy is provided.
Keywords
cancer, cervical cancer, HPV, Pap test.
| Item Type: | Conference or Workshop Item (Poster) |
|---|---|
| Uncontrolled Keywords: | cancer, cervical cancer, HPV, Pap test |
| Subjects: | Medical and Health Sciences > Basic medicine Medical and Health Sciences > Clinical medicine Medical and Health Sciences > Health sciences Medical and Health Sciences > Other medical sciences |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Prof. Dance Vasileva |
| Date Deposited: | 12 Feb 2016 11:24 |
| Last Modified: | 12 Feb 2016 11:24 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/15326 |
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