Velkoska Nakova, Valentina and Krstevska, Branka and Kostovska Srbinovska, Elizabeta and Vaskova, Olivija (2015) Assessment of left ventricular systolic and diastolic function in subclinical hypothyroidism. International Journal of Recent Scientific Research, 6 (11). pp. 7580-7585. ISSN 0976-3031
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Abstract
Objective: Studies investigating systolic and diastolic left ventricle function in subclinical
hypothyroidism (ScH) have shown controversial results. As myocardium is a target organ of thyroid
hormone action, the aim of the study was to assess the left ventricular systolic and diastolic function
in ScH.
Methods: Fifty-four patients with newly diagnosed ScH and 30 euthyroid controls, patients of the
University Clinic of the Endocrinology, Diabetes, and Metabolic Disorders Clinic were enrolled.
Transthoracic echocardiography, using M-mode, two-dimensional (2D), pulsed, continuous and
color-Doppler, and advanced echocardiographic modalities Tissue Doppler and two-dimensional
speckle tracking was performed in all subjects.
Results: Although normal echocardiographic values of all measured parameters, SCH patients were
significantly different from their matched controls: the ratio between E/A was statistically
significantly lower (1,26±0,36 vs. 1,03±0,29, p<0,01), the ratio between Е/е’ sep. was statistically
significantly higher (6,04±1,64 vs. 7,62±2,29, p<0,01), MPI was statistically significantly higher
(0,43±0,07 vs. 0,47±0,08, p<0,05), GLS had statistically significantly lower negative value (-20,9±1,7
vs. -19,55±2,3%, p<0,001), and S/TDI was statistically significantly lower (0,092±0,011 vs.
0,077±0,013, p<0,01). TSH negatively correlated with EF (r=-0,15, p<0,05), E/A(r=-0,14, p<0,05),
GLS (r=-0,26, p<0,001), S/TDI (r=-0,22, p<0,01), and positively correlated with E/e 'sep. (r=0,14,
p<0,05).
Conclusion: Subclinical hypothyroidism contributes to changes in certain parameters involved in the
assessment of global and longitudinal systolic and diastolic left ventricular function compared to
healthy individuals
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Valentina Velkovska |
| Date Deposited: | 26 Jan 2016 14:39 |
| Last Modified: | 26 Jan 2016 14:39 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/15040 |
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