Velkoska Nakova, Valentina and Krstevska, Branka and Kostovska Srbinovska, Elizabeta and Vaskova, Olivija and Jovanova, Silvana (2015) Influence of the Subclinical Hypothyroidism on the Left Ventricular Systolic and Diastolic Function (pilot study). Thyroid Disorders & Therapy, 4 (2). pp. 1-5. ISSN 2167-7948 JTDT
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Abstract
Introduction: The clinically manifested hypothyroidism is associated with systolic and diastolic dysfunction.
Studies investigating the left ventricular function in subclinical hypothyroidism (ScH) have shown controversial
results. The aim of the study was to assess whether ScH is associated with the left ventricular systolic and diastolic
dysfunction.
Material and methods: Seventeen consecutive patients with newly diagnosed ScH and 20 healthy euthyroid
patients as controls were analyzed. The two groups were appropriate by: age, sex, and body mass index. Laboratory
analyses were performed in all patients - determination of TSH, free thyroxin (FT4), free triijodothyronine (FT3),
antibodies directed to thyroid peroxidase (TPOAb) and antitiroglobulin antibodies (TgAb), and the assessment of
left ventricular systolic and diastolic function by M-mode, two-dimensional echocardiography, pulse, continuous and
color-Doppler, advanced echocardiographic modalities Tissue Doppler (TDI) and two-dimensional speckle tracking.
Results: ScH patients had statistically significant lower ejection fraction, smaller ratio s/d (where s is the systolic
velocity and d is the diastolic velocity through the pulmonary veins) and lower negative longitudinal global strain
compared with the control group (62.1 ± 2.1 vs. 58.7 ± 6.2%, p<0.05, 1.27 ± 0.12 vs. 1.06 ± 0.20, p<0.001, -0.21 ±
0.01 versus -0.19 ± 0.01%, p<0.05, respectively). There was a statistically significant negative correlation of TSH
with s/d and S/ TDI (r = 0.43 and r = 0.26, p<0.05, respectively). There was a statistically significant negative
correlation of free thyroxine with myocardial performance index (r = -0.17, p<0.05), and a positive correlatin with s/d
(r =0.48, p<0.05).
Conclusion: ScH was associated with a statistically significant reduction in global systolic and global longitudinal
systolic function of the left ventricle.
| Item Type: | Article |
|---|---|
| Subjects: | Medical and Health Sciences > Clinical medicine |
| Divisions: | Faculty of Medical Science |
| Depositing User: | Valentina Velkovska |
| Date Deposited: | 26 Jan 2016 14:15 |
| Last Modified: | 26 Jan 2016 14:15 |
| URI: | https://eprints.ugd.edu.mk/id/eprint/15039 |
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